DiReCCT is a working group of imaging specialists interested in (1) assessing advanced imaging techniques for imaging of the cardiovascular and pulmonary systems and (2) application of advancing technology on diagnosis and treatment of cardiovascular and oncologic disease.  Through collaborations with surgical and medical colleagues throughout Duke University Medical Center and industry partners we work to advance technology to better understand its application to cardiovascular and thoracic oncologic disease.

Established 2017
DUMC Durham NC

DUKE UNIVERSITY MEDICAL CENTER:

• Duke Multi-D laboratory
• DCRI, Multi-Imaging program
• Ravin Advanced Imaging Labs
• Duke Radiology Clinical Research Unit

INDUSTRY PARTNERS:

• Bracco
• GE Medical Systems
• Heartflow, Inc.
• Mallinkrodt Pharmaceuticals
• Siemens Healthineers
• Verily

SYSTEM ASSESSMENT

CARDIOVASCULAR DISEASE

Imaging for diagnosis and management of coronary arterial disease
Imaging for structural heart disease

THORACIC ONCOLOGIC DISEASE

Imaging for diagnosis and management of thoracic oncologic disease

TECHNOLOGY ASSESSMENT

ADVANCED MDCT TECHNOLOGY

Dual Energy CT for cardiovascular and solid organ assessment
Non-invasive assessment of blood flow characteristics in cardiovascular disease.

ADVANCED MR IMAGING

Non-invasive lymphatic imaging

TECHNOLOGY DISSEMINATION AND ACCESS

Understanding healthcare areas – disparities to Imaging
Assessing imaging resource availability with respect to at-need populations

MULTI-CENTER TRIAL PARTICIPATION

Assessing Diagnostic Value of Non-invasive FFRCT in Coronary CarE (ADVANCE)
International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (Ischemia)
Project Baseline

Transcatheter Aortic Valve Replacement with the Medtronics Transcatheter Aortic Valve Replacement System in patient at low risk for surgical aortic valve replacement.  LTI substudy

Transcatheter Mitral Valve Replacement with the Medtronic Intrepid TMVR in patients with severe symptomatic mitral regurgitation-APOLLO trial

REPRISE III CT-Substudy, TAVR imaging post stenting, evaluation of thrombus

Portico Re-sheathable Transcatheter Aortic Valve System US IDE Team

CORE LAB SUPPORT MULTI-CENTER TRIALS

We provide imaging support for both acquisition and interpretation for multicenter trials. Clinical Trial Core Laboratory Services are provided in collaboration with the DCRI, multi-imaging program.
The Baseline Study
Sponsor: Verily
Corelab for Chest X-ray Image Acquisition and Image Interpretation
Corelab for Calcium Scoring CT Image Acquisition and Image Interpretation
A Randomized Multicenter Blinded, Parallel, 2-Arm Proof of Concept Study to Assess the Effects of Gaseous Nitric Oxide (gNO) in an Ex Vivo System of Human Lung Transplants
Sponsor: Mallinckrodt Pharmaceuticals
Corelab for Chest X-ray Image Acquisition and Interpretation

Medical Director:
Lynne M. Hurwitz Koweek, MD
Manager:
Steven Shipes RT