Bashir Lab for Liver Imaging Research

Bashir Lab for Liver Imaging Research

Our laboratory focuses on advanced imaging methodologies in body imaging, especially MRI of the liver. We aim to further our understanding of existing techniques and develop novel imaging methods, in part through a rich group of collaborations with members of the Non-alcoholic Steatohepatitis Clinical Research Network (NASH CRN) and Liver Imaging Reporting and Data System (LI-RADS) committee.

Liver Quantification and Liver Fat

Our past collaborative efforts have led to the development and dissemination of a technique for quantifying hepatic steatosis. Animal and human data have linked features of the individual triglyceride chains to histopathological findings of NASH such as hepatocyte ballooning. This continuing line of research is now focused on characterizing the types of lipid deposited in the liver and in other fat depots throughout the body.

Clinical Trials Core Laboratory

We collaborate with industry partners on clinical trials in non-alcoholic steatohepatitis (NASH) and other liver diseases. Our role is typically to develop the imaging components of these clinical trials, including liver fat quantification, liver volume, adiposity measures, and liver stiffness by MR elastography. We seek to leverage this platform for the development of novel imaging methods relevant to a clinical trial’s patient population.

Liver Cancer

We seek to evolve our understanding of the features of liver cancer and improve imaging-based methods for the diagnosis and characterization of liver tumors. Using a deep learning approach, we hope to improve on existing imaging methods and diagnostic algorithms to improve the care of patients with liver cancer.

Contrast Agents

Intravenous contrast agents play a critical role in body imaging, particularly CT and MRI. With the introduction of novel contrast agents, the precise utility and roles of various agents remain poorly defined. We study the diagnostic applications and safety profiles associated with a variety of available agents.