Translational PET/CT Molecular Imaging Center

Overview

Facility Overview

FDG PET / CT is currently the “gold standard” tumor staging modality for the vast majority of patients with cancer.  Prior to June of 2013, most patients in need of clinical FDG PET / CT were faced with the “coverage under evidence development” (CED) reimbursement issue posed by the Centers for Medicare and Medicaid Services (CMS, commonly known as Medicare). The translation of this scientific imaging modality into clinical standard of care required over 2 decades.

A major goal of this center is to facilitate the acceleration of scientific discovery into clinical practice. Small animal PET / CT allows in vivo physiologic and anatomic imaging in preclinical rodent models. Using high resolution positron emission tomography (PET), we are able to image biological processes co-registered with high resolution CT images. Quantitative, in vivo measurements of physiologic processes can be performed in longitudinal studies.

Our Inveon PET / CT scanner allows for physiologic and anatomic imaging of mice and rats with a 1.4mm FWHM PET spatial resolution, and a 0.1 mm CT spatial resolution. This quantitative analysis can be performed on static, gated and dynamic data.

A few examples of the potential use of pre-clinical PET / CT include, but are not limited to:

  • Novel PET radionuclide discovery and development
  • Molecular imaging to optimize drug development in pre-clinical models of disease
  • Interrogation of mechanisms of disease through imaging of dysfunctional pathways
  • Development and validation of novel molecular agents (nanoparticles, optical, CT, MRI, radionuclide, or a combination thereof) for diagnosis and therapy
  • Development and validation of quantitative imaging techniques prior to clinical use
  • Testing, development and validation of image acquisition and processing algorithms
  • Testing clinical hypotheses of disease in preclinical models
  • Quantifying disease progression at a molecular level.

Located on the 1st floor of the Bryan Research Building (Room 0128), above the Vivarium, our research center provides accommodations for both immune competent and immunocompromised rodent models. Integrated small animal anesthesia using isofluorane, and continuous physiologic monitoring and support are also provided with our imaging service. Visualization software, supplied by the vendor, and data analysis tools are also available.

We welcome all Duke investigators and industrial partners to utilize or collaborate using this state-of-the-art technology. For more information regarding fees, please click here.

Fees & Services

Fees

Imaging and support services are available to all research investigators. For Duke and NIH supported investigators, cost for use of small animal PET / CT is $215 /hour. Additional support for complex data analysis, or additional animal support is $150/hour. For more information regarding fees for outside investigators, please contact Thomas Hawk by phone at (919) 684-7712 or email  thomas.hawk@duke.edu

Commercially available radiotracers (18F FDG, 18F NaF, 18F FLT), and a limited number of established PET radiotracers can be obtained through our facility.


Services

Study Initiation

Our staff will meet with you to discuss how PET imaging can assist you with:

  • Pre-clinical experimental goals
  • Designing an optimal imaging protocol
  • Achieving research goals with the coordination of all details of animal studies including IACUC amendments, protocol details, and animal transfers

Good coordination will facilitate cost- and time- effective research. Please contact Thomas Hawk by phone at (919) 684-7712 or email thomas.hawk@duke.edu  to set up an appointment or to receive a study initiation form.

Day-of Imaging

Radiotracers
The research facility staff will oversee all regulatory aspects of handling radioactive materials: the ordering and delivery of commercial radiotracers and radioactive disposal. Investigational radiotracers may be available depending upon requests.

Animals
Our Inveon scanner has the capability to image both mice and rats in which we may perform animal anesthesia and continuous biological monitoring during image acquisition.

Image Acquisition and Reconstruction

As we strive to perform cost-and time-effective imaging, the needs of your protocol define the acquisition and reconstruction parameters. Images are typically available within 24 hours of the acquisition and we will notify investigators when complete.

Image Analysis

We are also available to help analyze and interpret the image data. Starting with CT or PET based Region of Interest definition, we can:

  • Generate activity concentrations, standard uptake values, and time activity curves
  • Assist you with developing other analysis techniques
  • Export both images and processed data to meet your needs
  • Help prepare images for publication

About Us

Our Staff

Bennett Chin, M.D.
Associate Professor of Radiology
Director
DUMC Box 3949
Durham, NC 27710
Phone: (919) 684-7698
Email: chin0004@dm.duke.edu
Thomas Hawk
Computer Operations
DUMC Box 3949
0401 Hospital South
Durham, NC 27710
Phone: (919) 684-7712
Email: thomas.hawk@duke.edu
 
Simone Degan, PhD
Research Scientist, Molecular Biology
DUMC Box 3302
311 Research Drive
Durham, NC 27710
Phone: (919) 660-8459
Fax: (919) 684-7158
Email: simone.degan@duke.edu

Facilities

Siemens Inveon PET/CT system

The Inveon PET / CT system combines PET and CT modalities into a single gantry under the control of a single workstation, providing an optimal workflow solution for PET multimodal applications.

Image Analysis
The Research Workplace is an integrated review, fusion, and analysis package that can generate region of interest, time activity curves, and kinetic modeling of metabolic processes. A full suite of graphic applications allow for easy export of publication quality images. Image data is exportable in dicom format for analysis with other packages.

Additional Support
Our facilities include isofluorane vaporizers, a dose calibrator, balances, and heating pads for tail vein dilation and animal recovery.  We have dissection tools for ex vivo analysis of radiotracer uptake in tissues or tumors.  The Duke Division of Laboratory Animal Resources (DLAR) supported facility is in the basement of the Bryan building, so your animals can be quickly accessible for imaging studies.

Contact Info


Parking is available below the Bryan Research Building

Bryan Research Building
Duke University Medical Center
311 Research Drive, Room 0128
Durham, NC 27710

Hours of Operation:
Monday-Friday 8 AM to 5 PM

For more information regarding pre-clinical PET / CT fees and services or to schedule a consultation or service, please contact:

Thomas Hawk
Computer Operations
DUMC Box 3949
0401 Hospital South
Durham, NC 27710
Phone: (919) 684-7712
Email: thomas.hawk@duke.edu