Warren S. Warren, Ph.D., M.S., B.A.

  • James B. Duke Professor of Chemistry and Radiology and Professor of Biomedical Engineering
  • Director, Center for Molecular and Biomolecular Imaging
Department/Division
  • Research
Address French Family Science Center
124 Science Drive, Room 2217
Campus Box 90347

Durham, NC 27708
Telephone 919-660-1604
Fax 919-660-1605
National Roles
  • Fellow, American Physical Society
  • Fellow, International Society of Magnetic Resonance
  • Fellow, Optical Society of America
  • Fellow, International Society for Optics and Photonics
Awards and Honors
  • Innovation Award in Neuroscience, McKnight Foundation
  • Herbert Broiada Prize, American Physical Society
  • Nobel Laureate Signature Award, American Chemical Society
Education
  • A.B., Chemistry and Physics, Harvard University 1977
  • M.S., University of California, Berkeley 1979
  • Ph.D, University of California, Berkeley 1980
Research Interests Our work focuses on the development of next-generation imaging methods, using controlled radiation fields to alter dynamics. In magnetic resonance imaging, we have found new ways to enhance intrinsic contrast, letting us image temperature, brown fat concentration, and brain susceptibility structures. We have also developed "hyperpolarized" contrast agents which let us image biologically relevant molecules in vivo, instead of simply image water. In optical imaging, we have shown that sophisticated laser techniques can let us examine a mole and determine if it is melanoma, or stage the tumor for its metastatic potential; we have also extended this work to ocular applications. In every case our work combines insight from chemistry and physics with a focus on fundamental clinical questions.
Grants NIH, NSF
  • Simpson MJ, Wilson JW, Phipps MA, Robles FE, Selim MA, Warren WS. Nonlinear microscopy of eumelanin and pheomelanin with subcellular resolution. J Invest Dermatol. 2013 Jul;133(7):1822-6.
    Abstract
  • Feng Y, Theis T, Liang X, Wang Q, Zhou P, Warren WS. Storage of hydrogen spin polarization in long-lived (13)c2 singlet order and implications for hyperpolarized magnetic resonance imaging. J Am Chem Soc. 2013 Jul 3;135(26):9632-5.
    Abstract
  • Robles FE, Samineni P, Wilson JW, Warren WS. Pump-probe nonlinear phase dispersion spectroscopy. Opt Express. 2013 Apr 22;21(8):9353-64.
    Abstract
  • Wilson JW, Degan S, Warren WS, Fischer MC. Optical clearing of archive-compatible paraffin embedded tissue for multiphoton microscopy. Biomed Opt Express. 2012 Nov 1;3(11):2752-60.
    Abstract
  • Li B, Claytor KE, Yuan H, Vo-Dinh T, Warren WS, Fischer MC. Multicontrast nonlinear optical microscopy with a compact and rapid pulse shaper. Opt Lett. 2012 Jul 1;37(13):2763-5.
    Abstract
  • Stokes AM, Feng Y, Mitropoulos T, Warren WS. Enhanced refocusing of fat signals using optimized multipulse echo sequences. Magn Reson Med. 2013 Apr;69(4):1044-55.
    Abstract
  • Cho JH, Hong KS, Cho J, Chang SK, Cheong C, Lee NH, Kim H, Warren WS, Ahn S, Lee C. Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T. J Magn Reson. 2012 Apr;217:86-91.
    Abstract
  • Matthews TE, Wilson JW, Degan S, Simpson MJ, Jin JY, Zhang JY, Warren WS. In vivo and ex vivo epi-mode pump-probe imaging of melanin and microvasculature. Biomed Opt Express. 2011 Jun 1;2(6):1576-83.
    Abstract
  • Kurhanewicz J, Vigneron DB, Brindle K, Chekmenev EY, Comment A, Cunningham CH, Deberardinis RJ, Green GG, Leach MO, Rajan SS, Rizi RR, Ross BD, Warren WS, Malloy CR. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia. 2011 Feb;13(2):81-97.
    Abstract
  • Matthews TE, Piletic IR, Selim MA, Simpson MJ, Warren WS. Pump-probe imaging differentiates melanoma from melanocytic nevi. Sci Transl Med. 2011 Feb 23;3(71):71ra15.
    Abstract
  • Branca RT, Warren WS. In vivo NMR detection of diet-induced changes in adipose tissue composition. J Lipid Res. 2011 Apr;52(4):833-9.
    Abstract
  • Branca RT, Warren WS. In vivo brown adipose tissue detection and characterization using water-lipid intermolecular zero-quantum coherences. Magn Reson Med. 2011 Feb;65(2):313-9.
    Abstract
  • Jenista ER, Branca RT, Warren WS. Absolute temperature imaging using intermolecular multiple quantum MRI. Int J Hyperthermia. 2010;26(7):725-34.
    Abstract
  • Branca RT, Cleveland ZI, Fubara B, Kumar CS, Maronpot RR, Leuschner C, Warren WS, Driehuys B. Molecular MRI for sensitive and specific detection of lung metastases. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3693-7.
    Abstract
  • Branca RT, Chen YM, Mouraviev V, Galiana G, Jenista ER, Kumar C, Leuschner C, Warren WS. iDQC anisotropy map imaging for tumor tissue characterization in vivo. Magn Reson Med. 2009 Apr;61(4):937-43.
    Abstract