Joseph G. Mammarappallil, M.D., Ph.D.

  • Assistant Professor of Radiology
Department/Division
  • Cardiothoracic Imaging
Address DUMC Box 3808
Durham, NC 27710
Telephone 919-684-7218
Fax 919-684-7168
Training
  • MD, Texas Tech University Health Sciences Center, 2009
Residency
  • General Surgery Intern, Wake Forest Baptist Medical Center, 2010
  • Diagnostic Radiology, Wake Forest Baptist Medical Center, 2014
Fellowship
  • Cardiothoracic Imaging, Duke University Medical Center, 2015
National Roles
  • Radiological Society of North America, Daily Bulletin Editorial Board
Awards and Honors
  • Radiological Society of North America Research Scholar Grant Recipient, July 2018.
  • Reed P. Rice Memorial Award Presented to Junior Faculty Dedicated to Excellence in Resident Education. June 2018.
  • Reed P. Rice Memorial Award Presented to Junior Faculty Dedicated to Excellence in Resident Education. June 2017.
  • Roentgen Resident/Fellow Research Award in Recognition of Outstanding Radiologic Research. Radiological Society of North America Research & Education Foundation, June 2014.
  • Ernest and Jean Spangler Award for Commitment to Professional Development. Wake Forest Baptist Department of Radiology, June 2014.
  • Trainee Research Award for Best Resident Health Services Policy & Research Poster. Radiological Society of North America Research, 2011.
  • Student Research Week, “Best Medical Student Research Presentation”. Texas Tech University Health Sciences Center, 2008.
  • Student Research Week, “Best Medical Student Research Presentation”. Texas Tech University Health Sciences Center, 2007.
  • Phillip and Marjorie Newmark Award Finalist for Excellence in Research. University of Kansas Department of Molecular Biosciences, 2001.
  • Cassandra Ritter Award Recipient for Excellence in Research. University of Kansas Department of Molecular Biosciences, 2001.
  • “Best Graduate Student Research Presentation." Missouri Valley Branch of the American Society for Microbiology, 2000.
  • Sally K. Frost-Mason and Kenneth A. Mason Award for Excellence in Teaching Undergraduate Biology Core Laboratory. University of Kansas Department of Molecular Biosciences, 1999.
Education
  • Ph.D, University of Kansas, 2001
  • B.S., University of Illinois, 1996
Clinical Interests • CT-guided percutaneous biopsy
• Interstitial Lung Disease
• COPD
• Airways Disease
• Thoracic and Abdominal Vascular Assessment
• Cardiac CTA

Research Interests • Hyperpolarized 129Xe MR Imaging of the Lungs: We are currently studying the utilization of 129Xe in various pulmonary diseases including idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), COPD, and
pulmonary vascular disease. A current research goal is to use 129Xe as a diagnostic tool in pulmonary fibrosis.

• 19F MR Imaging of the Lungs: We are currently conducting a large research study of patients with COPD to determine global ventilation patterns that may better assess disease severity and responsiveness to treatment. An exciting
new direction of our research program is applying 19F MR to evaluate patients with suspected War-Lung Injury.

• Thoracic Ablation: The advent of immunotherapy has dramatically changed the treatment algorithms for lung cancer. We are currently evaluating the role of ablative therapies in the lung to stimulate tumor-specific T-cell responses
in the tumor microenvironment to increase immunotherapy responses.


Grants • Utilization of 19F MRI to Evaluate Iraq-Afghanistan War Lung Injury – Charles E. Putman, M.D. Seed Funded Research, Department of Radiology, Duke Medical Center. Principal Investigator.

• Utilization of Hyperpolarized 129Xe MRI for Diagnosis of Idiopathic Pulmonary Fibrosis – Research Scholar Grant, Radiological Society of North America. Principal Investigator.

• Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI – National Institutes of Health. Co-Investigator.

• Non-invasive Diagnosis of Pulmonary Vascular Disease Using Inhaled 129Xe MRI – National Institutes of Health. Co-Investigator.

• Using MRI To Visualize Regional Therapy Response in Idiopathic Pulmonary Fibrosis – National Institutes of Health. Co-Investigator.

• Human Lung Regional Ventilation Defect Severity Measured By Fluorine – 19 Gas MRI – National Institutes of Health. Co-Investigator.