James M. Provenzale, M.D., FACR

  • Professor of Radiology
  • Neuroradiology
Address DUMC Box 3808
Durham, NC 27710
Telephone 919-684-7647
Fax 919-684-7168
  • MD, Albany Medical College, 1983
  • Neurology, UNC Hospitals, 1984-1987
  • Radiology, Massachusetts General Hospital, 1987-1991
  • Neuroradiology, Massachusetts General Hospital, 1990-1992
National Roles
  • Associate Editor , American Journal of Roentgenology
Research Interests I have the following major research areas:
I. Diffusion tensor imaging (an MR technique that measures rate and direction of microscopic water motion) to examine white matter pathways in the brain. This technique is used by many investigators in an attempt to understand white matter microstructure. My recent work has centered on the histological correlation of DTI metrics. In addition, because DTI metrics can vary substantially within a single scanner at multiple time points as well as between scanners, my work is focused on understanding causes of such variability and designing methods to decrease it. 
Since 1998, I have mentored third-year students at Duke University School of Medicine (typically one medical student per year) in both DTI research and perfusion imaging research. Although the research techniques are highly advanced, our implementation of various "user-friendly" software programs allows students with little or no prior experience to analyze data in a productive manner. Our research is also well-suited to individuals with advanced computer skills or an interest in biomedical or electrical engineering. Students work closely with research personnel on a daily basis. They also meet with collaborators from various basic science and clinical departments and me in a laboratory meeting once a week. The focus of these meetings is to plan experiments, refine research methods, discuss experimental results and prepare manuscripts. Students serve as first authors or co-authors on manuscripts based on their specific research project. The results of a number of such projects have been published.

II. Applications of nanotechnology to treatment of cancer (both CNS and non-CNS) and brain disorders. My research involves design and implementation of nanoparticles and fluorescent molecules for cancer diagnosis and therapy. Although I am trained as a neurologist and neuroradiologist, most of my nanotechnology-based research is oriented towards non-CNS tumors such as breast cancer and sarcomas. In the past few years, my Emory and Georgia Tech colleagues and I have conducted research using animals with naturally-occurring tumors at the University of Georgia College of Veterinary Medicine. This work has focused on the use of a handheld device to detect fluorophores that are administered intravenously prior to surgery. We are presently validating the use of this combination of imaging device and contrast agent to guide surgical resection of tumors. I am also interested in development of nanotechnology-based non-invasive and minimally invasive devices that can continuously monitor tumor physiological characteristics and response to therapy. This work is done in conjunction with a number of colleagues in Biomedical Engineering at both Duke and Emory and supported by a number of NIH grants. Finally, I have a strong interest in use of nanotechnology for tissue engineering and regenerative medicine. 
  • Wasserstein MP, Andriola M, Arnold G, Aron A, Duffner P, Erbe RW, Escolar ML, Estrella L, Galvin-Parton P, Iglesias A, Kay DM, Kronn DF, Kurtzberg J, Kwon JM, Langan TJ, Levy PA, Naidich TP, Orsini JJ, Pellegrino JE, Provenzale JM, Wenger DA, Caggana M. Clinical outcomes of children with abnormal newborn screening results for Krabbe disease in New York State. doi: 10.1038/gim.2016.35. 2016 May 12; Abstract
  • Soares BP, Provenzale JM. Imaging of Herpesvirus Infections of the CNS. doi: 10.2214/AJR.15.15314. 2016 Jan;206(1):39-48 Abstract
  • Peterson DE, Chen SD, Calabrese E, White LE, Provenzale JM. Automated segmentation of the canine corpus callosum for the measurement of diffusion tensor imaging. doi: 10.1177/1971400915610924. 2016 Feb;29(1):4-12 Abstract
  • De Bellis MD, Hooper SR, Chen SD, Provenzale JM, Boyd BD, Glessner CE, MacFall JR, Payne ME, Rybczynski R, Woolley DP. Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder. doi: 10.1017/S0954579415000942. 2015 Nov;27(4 Pt 2):1555-76 Abstract
  • Hacein-Bey L, Varelas PN, Ulmer JL, Mark LP, Raghavan K, Provenzale JM. Imaging of Cerebrovascular Disease in Pregnancy and the Puerperium. doi: 10.2214/AJR.15.15059. 2016 Jan;206(1):26-38 Abstract
  • Choi J, Dickson P, Calabrese E, Chen S, White L, Ellingwood M, Provenzale JM. Predicting degree of myelination based on diffusion tensor imagining of canines with mucopolysaccharidosis type I. doi: 10.1177/1971400915609351. 2015 Dec;28(6):562-73 Abstract
  • Provenzale JM, Nestrasil I, Chen S, Kan SH, Le SQ, Jens JK, Snella EM, Vondrak KN, Yee JK, Vite CH, Elashoff D, Duan L, Wang RY, Ellinwood NM, Guzman MA, Shapiro EG, Dickson PI. Diffusion tensor imaging and myelin composition analysis reveal abnormal myelination in corpus callosum of canine mucopolysaccharidosis I. doi: 10.1016/j.expneurol.2015.07.021. 2015 Nov;273:1-10 Abstract
  • Leong D, Calabrese E, White LE, Wei P, Chen S, Platt SR, Provenzale JM. Correlation of diffusion tensor imaging parameters in the canine brain. doi: 10.15274/NRJ-2014-10110. 2015 Feb;28(1):12-8 Abstract
  • Wintermark M, Coombs L, Druzgal TJ, Field AS, Filippi CG, Hicks R, Horton R, Lui YW, Law M, Mukherjee P, Norbash A, Riedy G, Sanelli PC, Stone JR, Sze G, Tilkin M, Whitlow CT, Wilde EA, York G, Provenzale JM, American College of Radiology Head Injury Institute. Traumatic brain injury imaging research roadmap. doi: 10.3174/ajnr.A4254. 2015 Mar;36(3):E12-23 Abstract
  • Mohs AM, Mancini MC, Provenzale JM, Saba CF, Cornell KK, Howerth EW, Nie S. An integrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors. doi: 10.1109/TBME.2015.2389626. 2015 May;62(5):1416-24 Abstract
  • Hill TK, Abdulahad A, Kelkar SS, Marini FC, Long TE, Provenzale JM, Mohs AM. Indocyanine green-loaded nanoparticles for image-guided tumor surgery. doi: 10.1021/bc5005679. 2015 Feb 18;26(2):294-303 Abstract
  • Kranz PG, Amrhein TJ, Provenzale JM. Spontaneous brain parenchymal hemorrhage: an approach to imaging for the emergency room radiologist. doi: 10.1007/s10140-014-1245-x. 2015 Feb;22(1):53-63 Abstract
  • Shiroishi MS, Castellazzi G, Boxerman JL, D'Amore F, Essig M, Nguyen TB, Provenzale JM, Enterline DS, Anzalone N, Dörfler A, Rovira À, Wintermark M, Law M. Principles of T2 *-weighted dynamic susceptibility contrast MRI technique in brain tumor imaging. doi: 10.1002/jmri.24648. 2015 Feb;41(2):296-313 Abstract
  • Pierce T, Kranz PG, Roth C, Leong D, Wei P, Provenzale JM. Use of apparent diffusion coefficient values for diagnosis of pediatric posterior fossa tumors. 2014 Apr;27(2):233-44. Abstract
  • Pierce TT, Provenzale JM. Evaluation of apparent diffusion coefficient thresholds for diagnosis of medulloblastoma using diffusion-weighted imaging. 2014 Feb;27(1):63-74. Abstract
  • Pierce TT, Calabrese E, White LE, Chen SD, Platt SR, Provenzale JM. Segmentation of the canine corpus callosum using diffusion-tensor imaging tractography. doi: 10.2214/AJR.12.9791. 2014 Jan;202(1):W19-25 Abstract
  • Moriarty JC, Langleben DD, Provenzale JM. Brain trauma, PET scans and forensic complexity. doi: 10.1002/bsl.2089. 2013 Nov-Dec;31(6):702-20 Abstract
  • Essig M, Nguyen TB, Shiroishi MS, Saake M, Provenzale JM, Enterline DS, Anzalone N, Dörfler A, Rovira À, Wintermark M, Law M. Perfusion MRI: the five most frequently asked clinical questions. doi: 10.2214/AJR.12.9544. 2013 Sep;201(3):W495-510 Abstract
  • Cao Y, Eble JM, Moon E, Yuan H, Weitzel DH, Landon CD, Nien CY, Hanna G, Rich JN, Provenzale JM, Dewhirst MW. Tumor cells upregulate normoxic HIF-1α in response to doxorubicin. doi: 10.1158/0008-5472.CAN-12-1345. 2013 Oct 15;73(20):6230-42 Abstract
  • Urger E, Debellis MD, Hooper SR, Woolley DP, Chen S, Provenzale JM. Influence of analysis technique on measurement of diffusion tensor imaging parameters. doi: 10.2214/AJR.12.9650. 2013 May;200(5):W510-7 Abstract
  • Vite CH, Nestrasil I, Mlikotic A, Jens JK, Snella EM, Gross W, Shapiro EG, Kovac V, Provenzale JM, Chen S, Le SQ, Kan SH, Banakar S, Wang RY, Haskins ME, Ellinwood NM, Dickson PI. Features of brain MRI in dogs with treated and untreated mucopolysaccharidosis type I. 2013 Apr;63(2):163-73. Abstract
  • Tridandapani S, Ramamurthy S, Galgano SJ, Provenzale JM. Increasing rate of detection of wrong-patient radiographs: use of photographs obtained at time of radiography. doi: 10.2214/AJR.12.9521. 2013 Apr;200(4):W345-52 Abstract
  • Ramamurthy S, Bhatti P, Arepalli CD, Salama M, Provenzale JM, Tridandapani S. Integrating patient digital photographs with medical imaging examinations. doi: 10.1007/s10278-013-9579-6. 2013 Oct;26(5):875-85 Abstract
  • Martin HR, Poe MD, Provenzale JM, Kurtzberg J, Mendizabal A, Escolar ML. Neurodevelopmental outcomes of umbilical cord blood transplantation in metachromatic leukodystrophy. doi: 10.1016/j.bbmt.2013.01.010. 2013 Apr;19(4):616-24 Abstract
  • Essig M, Shiroishi MS, Nguyen TB, Saake M, Provenzale JM, Enterline D, Anzalone N, Dörfler A, Rovira A, Wintermark M, Law M. Perfusion MRI: the five most frequently asked technical questions. doi: 10.2214/AJR.12.9543. 2013 Jan;200(1):24-34 Abstract
  • Jean SM, Preuss TM, Sharma P, Anderson DC, Provenzale JM, Strobert E, Ross SR, Stroud FC. Cerebrovascular accident (stroke) in captive, group-housed, female chimpanzees. 2012 Aug;62(4):322-9. Abstract
  • Provenzale JM, Isaacson J, Stinnett S, Chen S. Analysis of corpus callosum diffusion tensor imaging parameters in infants. 2012 Jul;25(3):342-50. Abstract
  • Provenzale JM, Isaacson J, Chen S. Progression of corpus callosum diffusion-tensor imaging values during a period of signal changes consistent with myelination. doi: 10.2214/AJR.11.7849. 2012 Jun;198(6):1403-8 Abstract
  • Leiva-Salinas C, Provenzale JM, Kudo K, Sasaki M, Wintermark M. The alphabet soup of perfusion CT and MR imaging: terminology revisited and clarified in five questions. doi: 10.1007/s00234-012-1028-6. 2012 Sep;54(9):907-18 Abstract
  • Provenzale JM, Mancini MC. Assessment of intra-observer variability in measurement of high-grade brain tumors. doi: 10.1007/s11060-012-0843-2. 2012 Jul;108(3):477-83 Abstract
  • Folio L, Fischer T, Shogan PJ, Frew M, Bunger R, Provenzale JM. Cartesian positioning system for localization of blast and ballistic fragments: a phantom-based pilot study. 2011 Nov;176(11):1300-5. Abstract
  • Moon WJ, Provenzale JM, Sarikaya B, Ihn YK, Morlese J, Chen S, DeBellis MD. Diffusion-tensor imaging assessment of white matter maturation in childhood and adolescence. doi: 10.2214/AJR.10.6382. 2011 Sep;197(3):704-12 Abstract
  • Provenzale JM, Kranz PG. Understanding errors in diagnostic radiology: proposal of a classification scheme and application to emergency radiology. doi: 10.1007/s10140-011-0974-3. 2011 Oct;18(5):403-8 Abstract
  • Folio LR, Fischer T, Shogan P, Frew M, Dwyer A, Provenzale JM. Blast and ballistic trajectories in combat casualties: a preliminary analysis using a cartesian positioning system with MDCT. doi: 10.2214/AJR.10.5959. 2011 Aug;197(2):W233-40 Abstract
  • Holt RL, Provenzale JM, Veerapandiyan A, Moon WJ, De Bellis MD, Leonard S, Gallentine WB, Grant GA, Egger H, Song AW, Mikati MA. Structural connectivity of the frontal lobe in children with drug-resistant partial epilepsy. doi: 10.1016/j.yebeh.2011.03.016. 2011 May;21(1):65-70 Abstract
  • Folio LR, Fischer TV, Shogan PJ, Frew MI, Kang PS, Bunger R, Provenzale JM. CT-based ballistic wound path identification and trajectory analysis in anatomic ballistic phantoms. doi: 10.1148/radiol.10100534. 2011 Mar;258(3):923-9 Abstract
  • Leiva-Salinas C, Provenzale JM, Wintermark M. Responses to the 10 most frequently asked questions about perfusion CT. doi: 10.2214/AJR.10.5705. 2011 Jan;196(1):53-60 Abstract
  • Provenzale JM, Sarikaya B, Hacein-Bey L, Wintermark M. Causes of misinterpretation of cross-sectional imaging studies for dissection of the craniocervical arteries. doi: 10.2214/AJR.10.5384. 2011 Jan;196(1):45-52 Abstract
  • Hacein-Bey L, Provenzale JM. Current imaging assessment and treatment of intracranial aneurysms. doi: 10.2214/AJR.10.5329. 2011 Jan;196(1):32-44 Abstract
  • Provenzale JM, Kranz PG. Dural sinus thrombosis: sources of error in image interpretation. doi: 10.2214/AJR.10.5323. 2011 Jan;196(1):23-31 Abstract
  • Dickson PI, Pariser AR, Groft SC, Ishihara RW, McNeil DE, Tagle D, Griebel DJ, Kaler SG, Mink JW, Shapiro EG, Bjoraker KJ, Krivitzky L, Provenzale JM, Gropman A, Orchard P, Raymond G, Cohen BH, Steiner RD, Goldkind SF, Nelson RM, Kakkis E, Patterson MC. Research challenges in central nervous system manifestations of inborn errors of metabolism. doi: 10.1016/j.ymgme.2010.11.164. 2011 Mar;102(3):326-38 Abstract
  • Provenzale JM, Isaacson J, Chen S, Stinnett S, Liu C. Correlation of apparent diffusion coefficient and fractional anisotropy values in the developing infant brain. doi: 10.2214/AJR.10.4886. 2010 Dec;195(6):W456-62 Abstract
  • Provenzale JM. Revising a manuscript: ten principles to guide success for publication. doi: 10.2214/AJR.10.5553. 2010 Dec;195(6):W382-7 Abstract
  • Mohs AM, Mancini MC, Singhal S, Provenzale JM, Leyland-Jones B, Wang MD, Nie S. Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration. doi: 10.1021/ac102058k. 2010 Nov 1;82(21):9058-65 Abstract
  • Mohs AM, Provenzale JM. Applications of nanotechnology to imaging and therapy of brain tumors. doi: 10.1016/j.nic.2010.04.002. 2010 Aug;20(3):283-92 Abstract
  • Provenzale JM. Proposal of a method for deciding whether an AJR manuscript merits publication: The 25% rule. doi: 10.2214/AJR.10.4280. 2010 Aug;195(2):278-80 Abstract
  • Provenzale JM. Imaging findings of structural causes of epilepsy in children: a guide for the radiologist in the emergency room. doi: 10.1007/s10140-010-0884-9. 2010 Nov;17(6):479-86 Abstract
  • Provenzale JM. Imaging evaluation of the patient with worst headache of life--it's not all subarachnoid hemorrhage. doi: 10.1007/s10140-010-0882-y. 2010 Sep;17(5):403-12 Abstract
  • Provenzale JM, Stinnett SS, Engelter ST. Use of decrease in apparent diffusion coefficient values to predict infarct age. doi: 10.1007/s10140-010-0869-8. 2010 Sep;17(5):391-5 Abstract