H. Cecil Charles, Ph.D.

  • Associate Professor of Radiology
  • Co-Director, Center for Advanced Magnetic Resonance Development
  • Director, Duke Image Analysis Laboratory
Department/Division
  • Research
Address Duke Image Analysis Laboratory
Duke University Hock Plaza, Suite 301
2424 Erwin Road
Durham, NC 27705

DUMC Box 2702

Durham, NC 27710
Telephone 919-684-7921
Fax 919-684-7147
Education
  • Ph.D., University of New Orleans, 1981
Research Interests Dr. Charles is an Associate Professor of Radiology, a chemist, and an expert in MR imaging and spectroscopy with over 35 years of experience in nuclear magnetic resonance including MRI and MRS. He has extensive experience in conducting imaging and spectroscopy studies, and conducting longitudinal clinical trials with MRI and MRS used as imaging biomarkers. Current interest include functional lung imaging using perfluorinated gases.

He is the director of the Duke Image Analysis Laboratory which is active in conducting clinical trials in CNS disorders (schizophrenia, MCI, AD), cancer, osteoarthritis and lung disease using imaging based biomarkers. His lab recently initiated a new project in imaging lung ventilation in humans with 19F MRI.
  • Kraus VB, Feng S, Wang S, White S, Ainslie M, Brett A, Holmes A, Charles HC. Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progression. Arthritis Rheum. 2009 Dec;60(12):3711-22.
    Abstract
  • Chuckpaiwong B, Charles HC, Kraus VB, Guilak F, Nunley JA. Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI. J Orthop Res. 2010 Sep;28(9):1149-54.
    Abstract
  • Buck RJ, Wyman BT, Le Graverand MP, Wirth W, Eckstein F, A9001140 Investigators. An efficient subset of morphological measures for articular cartilage in the healthy and diseased human knee. Magn Reson Med. 2010 Mar;63(3):680-90.
    Abstract
  • Wyatt C, Soher B, Maccarini P, Charles HC, Stauffer P, Macfall J. Hyperthermia MRI temperature measurement: evaluation of measurement stabilisation strategies for extremity and breast tumours. Int J Hyperthermia. 2009;25(6):422-33.
    Abstract
  • Hellio Le Graverand MP, Buck RJ, Wyman BT, Vignon E, Mazzuca SA, Brandt KD, Piperno M, Charles HC, Hudelmaier M, Hunter DJ, Jackson C, Kraus VB, Link TM, Majumdar S, Prasad PV, Schnitzer TJ, Vaz A, Wirth W, Eckstein F. Subregional femorotibial cartilage morphology in women--comparison between healthy controls and participants with different grades of radiographic knee osteoarthritis. Osteoarthritis Cartilage. 2009 Sep;17(9):1177-85.
    Abstract
  • Le Graverand MP, Buck RJ, Wyman BT, Vignon E, Mazzuca SA, Brandt KD, Piperno M, Charles HC, Hudelmaier M, Hunter DJ, Jackson C, Kraus VB, Link TM, Majumdar S, Prasad PV, Schnitzer TJ, Vaz A, Wirth W, Eckstein F. Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography. Ann Rheum Dis. 2010 Jan;69(1):155-62.
    Abstract
  • Kraus VB, Feng S, Wang S, White S, Ainslie M, Graverand MP, Brett A, Eckstein F, Hunter DJ, Lane NE, Taljanovic MS, Schnitzer T, Charles HC. Subchondral bone trabecular integrity predicts and changes concurrently with radiographic and magnetic resonance imaging-determined knee osteoarthritis progression. Arthritis Rheum. 2013 Jul;65(7):1812-21.
    Abstract
  • Eckstein F, Le Graverand MP, Charles HC, Hunter DJ, Kraus VB, Sunyer T, Nemirovskyi O, Wyman BT, Buck R, A9001140, investigators. Clinical, radiographic, molecular and MRI-based predictors of cartilage loss in knee osteoarthritis. Ann Rheum Dis. 2011 Jul;70(7):1223-30.
    Abstract
  • Mazzuca SA, Hellio Le Graverand MP, Vignon E, Hunter DJ, Jackson CG, Kraus VB, Link TM, Schnitzer TJ, Vaz A, Charles HC. Performance of a non-fluoroscopically assisted substitute for the Lyon schuss knee radiograph: quality and reproducibility of positioning and sensitivity to joint space narrowing in osteoarthritic knees. Osteoarthritis Cartilage. 2008 Dec;16(12):1555-9.
    Abstract
  • Eckstein F, Buck RJ, Burstein D, Charles HC, Crim J, Hudelmaier M, Hunter DJ, Hutchins G, Jackson C, Kraus VB, Lane NE, Link TM, Majumdar LS, Mazzuca S, Prasad PV, Schnitzer TJ, Taljanovic MS, Vaz A, Wyman B, Le Graverand MP, A9001140 Study Group. Precision of 3.0 Tesla quantitative magnetic resonance imaging of cartilage morphology in a multicentre clinical trial. Ann Rheum Dis. 2008 Dec;67(12):1683-8.
    Abstract
  • Le Graverand MP, Vignon EP, Brandt KD, Mazzuca SA, Piperno M, Buck R, Charles HC, Hunter DJ, Jackson CG, Kraus VB, Link TM, Schnitzer TJ, Vaz A, Wyman B. Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees. Ann Rheum Dis. 2008 Nov;67(11):1562-6.
    Abstract
  • Charles HC, Kraus VB, Ainslie M, Hellio Le Graverand-Gastineau MP. Optimization of the fixed-flexion knee radiograph. Osteoarthritis Cartilage. 2007 Nov;15(11):1221-4.
    Abstract
  • Eckstein F, Buck RJ, Wyman BT, Kotyk JJ, Le Graverand MP, Remmers AE, Evelhoch JL, Hudelmaier M, Charles HC. Quantitative imaging of cartilage morphology at 3.0 Tesla in the presence of gadopentate dimeglumine (Gd-DTPA). Magn Reson Med. 2007 Aug;58(2):402-6.
    Abstract
  • Halaweish AF, Moon R, Foster WM, Soher BJ, McAdams HP, Macfall J, Ainslie MD, Macintyre NR, Charles HC. Perfluoropropane gas as a Magnetic Resonance Lung Imaging Contrast Agent in Humans. Chest. 2013 May 30;.
    Abstract