Christopher D. Lascola, M.D., Ph.D.

  • Assistant Professor of Radiology
  • Assistant Professor of Neurobiology
  • Director, Molecular Neuroimaging Laboratory
Department/Division
  • Neuroradiology
Address DUMC Box 3808
Durham, NC 27710
Telephone 919-684-7218
Nurse Line: 919-684-7770
Appointments: 919-684-7214
Fax 919-684-7168
Training
  • MD, University of Chicago Pritzker School of Medicine, 1998
Residency
  • Diagnostic Radiology, Duke University Medical Center, 1999-2003
Fellowship
  • Neuroradiology, Duke University Medical Center, 2003-2004
National Roles
  • Chair, Neuroradiology Scientific Subcommittee, American Roentgen Ray Society
  • Subcommittee Member, Neuroradiology Scientific , Radiological Society of North America
Education
  • PhD, Neurobiology, University of Chicago, 1997
Clinical Interests
  • MRI and CT imaging of brain and spine
  • CT and conventional fluoroscope-guided spine procedures
  • Angiography
  • Molecular imaging
    • Xie Y, Li YJ, Lei B, Kernagis D, Liu WW, Bennett ER, Venkatraman T, Lascola CD, Laskowitz DT, Warner DS, James ML. Sex Differences in Gene and Protein Expression After Intracerebral Hemorrhage in Mice. doi: 10.1007/s12975-018-0633-z. 2018 May 13; Abstract
    • McClung JM, McCord TJ, Ryan TE, Schmidt CA, Green TD, Southerland KW, Reinardy JL, Mueller SB, Venkatraman TN, Lascola CD, Keum S, Marchuk DA, Spangenburg EE, Dokun A, Annex BH, Kontos CD. BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. doi: 10.1161/CIRCULATIONAHA.116.024873. 2017 Jul 18;136(3):281-296 Abstract
    • Lei B, James ML, Liu J, Zhou G, Venkatraman TN, Lascola CD, Acheson SK, Dubois LG, Laskowitz DT, Wang H. Erratum: Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage. doi: 10.1038/srep39580. 2017 Jan 5;7:39580 Abstract
    • Lei B, James ML, Liu J, Zhou G, Venkatraman TN, Lascola CD, Acheson SK, Dubois LG, Laskowitz DT, Wang H. Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage. doi: 10.1038/srep34834. 2016 Oct 7;6:34834 Abstract
    • Tovmasyan A, Sampaio RS, Boss MK, Bueno-Janice JC, Bader BH, Thomas M, Reboucas JS, Orr M, Chandler JD, Go YM, Jones DP, Venkatraman TN, Haberle S, Kyui N, Lascola CD, Dewhirst MW, Spasojevic I, Benov L, Batinic-Haberle I. Anticancer therapeutic potential of Mn porphyrin/ascorbate system. doi: 10.1016/j.freeradbiomed.2015.10.416. 2015 Dec;89:1231-47 Abstract
    • Hsieh JT, Lei B, Sheng H, Venkatraman T, Lascola CD, Warner DS, James ML. Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage. doi: 10.1159/000440883. 2016;103(5):518-30 Abstract
    • Betof AS, Lascola CD, Weitzel D, Landon C, Scarbrough PM, Devi GR, Palmer G, Jones LW, Dewhirst MW. Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise. pii: djv040. doi: 10.1093/jnci/djv040. 2015 May;107(5) Abstract
    • Lei B, Sheng H, Wang H, Lascola CD, Warner DS, Laskowitz DT, James ML. Intrastriatal injection of autologous blood or clostridial collagenase as murine models of intracerebral hemorrhage. doi: 10.3791/51439. 2014 Jul 3;(89) Abstract
    • Bartels K, Ma Q, Venkatraman TN, Campos CR, Smith L, Cannon RE, Podgoreanu MV, Lascola CD, Miller DS, Mathew JP. Effects of deep hypothermic circulatory arrest on the blood brain barrier in a cardiopulmonary bypass model--a pilot study. doi: 10.1016/j.hlc.2014.04.131. 2014 Oct;23(10):981-4 Abstract
    • Wang H, James ML, Venkatraman TN, Wilson LJ, Lyuboslavsky P, Myers SJ, Lascola CD, Laskowitz DT. pH-sensitive NMDA inhibitors improve outcome in a murine model of SAH. doi: 10.1007/s12028-013-9944-9. 2014 Feb;20(1):119-31 Abstract
    • Wang H, Anderson LG, Lascola CD, James ML, Venkatraman TN, Bennett ER, Acheson SK, Vitek MP, Laskowitz DT. ApolipoproteinE mimetic peptides improve outcome after focal ischemia. doi: 10.1016/j.expneurol.2012.11.027. 2013 Mar;241:67-74 Abstract
    • Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP, Pearlstein RD, Sheng H, Warner DS. Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. doi: 10.1097/ALN.0b013e3182746b81. 2012 Dec;117(6):1262-75 Abstract
    • Hoang JK, Massoglia DP, Apostol MA, Lascola CD, Eastwood JD, Kranz PG. CT-guided cervical transforaminal steroid injections: where should the needle tip be located? doi: 10.3174/ajnr.A3266. 2013 Mar;34(3):688-92 Abstract
    • Freeman JJ, Kilani RK, Lascola CD, Gray L, Enterline DS. Trends in spinal pain management injections in academic radiology departments. doi: 10.3174/ajnr.A3167. 2013 Jan;34(1):247-51 Abstract
    • Jones LW, Antonelli J, Masko EM, Broadwater G, Lascola CD, Fels D, Dewhirst MW, Dyck JR, Nagendran J, Flores CT, Betof AS, Nelson ER, Pollak M, Dash RC, Young ME, Freedland SJ. Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. doi: 10.1152/japplphysiol.01575.2011. 2012 Jul;113(2):263-72 Abstract
    • Hoang JK, Yoshizumi TT, Toncheva G, Gray L, Gafton AR, Huh BK, Eastwood JD, Lascola CD, Hurwitz LM. Radiation dose exposure for lumbar spine epidural steroid injections: a comparison of conventional fluoroscopy data and CT fluoroscopy techniques. doi: 10.2214/AJR.10.6102. 2011 Oct;197(4):778-82 Abstract
    • Harreld JH, Kilani RK, Lascola CD, Bartz SK. MR imaging of fetal goiter. doi: 10.3174/ajnr.A2646. 2011 Sep;32(8):E160 Abstract
    • Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. doi: 10.1038/nature09965. 2011 Apr 28;472(7344):437-42 Abstract
    • Hoang JK, Apostol MA, Kranz PG, Kilani RK, Taylor JN, Gray L, Lascola CD. CT fluoroscopy-assisted cervical transforaminal steroid injection: tips, traps, and use of contrast material. doi: 10.2214/AJR.10.4369. 2010 Oct;195(4):888-94 Abstract
    • James ML, Wang H, Venkatraman T, Song P, Lascola CD, Laskowitz DT. Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. doi: 10.1089/neu.2009.1022. 2010 Jan;27(1):217-28 Abstract
    • James ML, Sullivan PM, Lascola CD, Vitek MP, Laskowitz DT. Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. doi: 10.1161/STROKEAHA.108.530402. 2009 Feb;40(2):632-9 Abstract
    • Lascola CD. Diffusion tensor tractography: exploring the cost-benefit ratio of incorporating CSF suppression into fiber tracing algorithms. 2005 Apr;26(4):693-4. Abstract
    • Lascola CD, Song AW, Haystead TA, Warner DS, Verleysen K, Freed TA, Provenzale JM. Changes in magnetization transfer MRI correlate with spreading depression-induced astroglial reactivity and increased protein expression in mice. 2004 Dec;183(6):1791-7 Abstract
    • Lascola CD, Nelson DJ, Kraig RP. Cytoskeletal actin gates a Cl- channel in neocortical astrocytes. 1998 Mar 1;18(5):1679-92. Abstract
    • Lascola CD, Kraig RP. Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology. 1996 Apr 15;16(8):2532-45. Abstract
    • Reder AT, Lascola CD, Flanders SA, Maimone D, Jensen MA, Skias DD, Lancki DW. Astrocyte cytolysis by MHC class II-specific mouse T cell clones. 1993 Aug;56(2):393-9. Abstract