Alexandra Badea, Ph.D.

  • Assistant Professor of Radiology
Department/Division
  • Research
Address Duke University Medical Center, Box 3302
Durham, NC 27710
Telephone 919-684-7654
Training
  • Ph.D., University of Patras (Greece), 2003
Research Interests My interest lies primarily in using MR microscopy to image the rodent brain, including its vasculature, so as to provide comprehensive morphometric phenotyping. I study the morphometry of the rodent brain, its anatomical variability in normal states, and also in human disease models. These studies require several steps: imaging protocols for optimal contrast, brain segmentation, registration, statistical analysis, and atlasing. Ultimately we should be able to quantify changes during normal development, aging, disease progression and to assess treatment effect in a quantitative fashion. By combining imaging data with behavioral and genetic tools we have a truly interdisciplinary approach in our translational studies.
Grants
  • Kahn Neurotechnology Development Award to Vann Bennett, and Alexandra Badea for "Brain Morphometry and Connectomics of Spectrin- and Ankyrin-Deficient Mice" 2016-2017
  • Quantitative MR Microscopy of Phenotypic Biomarkers in Alzheimer's Disease awarded by National Institutes of Health 2013 - 2018
  • Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary Fibrosis awarded by National Institutes of Health 2015 - 2019
  • Wang X, Bey AL, Katz BM, Badea A, Kim N, David LK, Duffney LJ, Kumar S, Mague SD, Hulbert SW, Dutta N, Hayrapetyan V, Yu C, Gaidis E, Zhao S, Ding JD, Xu Q, Chung L, Rodriguiz RM, Wang F, Weinberg RJ, Wetsel WC, Dzirasa K, Yin H, Jiang YH. Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. doi: 10.1038/ncomms11459. 2016 May 10;7:11459 Abstract
  • Badea A, Johnson GA, Jankowsky JL. Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease. doi: 10.1016/j.neuroimage.2009.12.070. 2010 Apr 1;50(2):416-27 Abstract
  • Badea A, Ali-Sharief AA, Johnson GA. Morphometric analysis of the C57BL/6J mouse brain. 2007 Sep 1;37(3):683-93 Abstract
  • Bae MH, Pan R, Wu T, Badea A, Automated segmentation of mouse brain images using extended MRF. doi: 10.1016/j.neuroimage.2009.02.012. 2009 Jul 1;46(3):717-25 Abstract
  • Badea A, Johnson GA, Williams RW. Genetic dissection of the mouse brain using high-field magnetic resonance microscopy. doi: 10.1016/j.neuroimage.2009.01.021. 2009 May 1;45(4):1067-79 Abstract
  • Badea A, Gewalt S, Avants BB, Cook JJ, Johnson GA. Quantitative mouse brain phenotyping based on single and multispectral MR protocols. doi: 10.1016/j.neuroimage.2012.07.021. 2012 Nov 15;63(3):1633-45 Abstract